147118-37-4, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 147118-37-4 as follows.
Example 7 Preparation of Compound of Formula (8B2) [0152] [0153] 2.5 g aldehyde compound, 3.6 g chiral diol sulfone (1a-B) and 50 mL THF were taken in round bottom flask at 35 C. under nitrogen atmosphere. The reaction mixture was cooled to -70 C. to -78 C. and treated with 10 g of NaH. The reaction mixture was stirred for 7-8 hours and quenched with ammonium chloride after completion of the reaction as monitored by TLC. The layers were separated at room temperature followed by washing organic layer with saturated sodium 38 mL saturated sodium bicarbonate solution. The organic layer was distilled under vacuum below 50 C. The solid residue 7.1 g was treated with 35 mL methanol and heated at 55 C. for 1 hour, cooled back to 0 C. and stirred for 1 hour. The isolated product was filtered and washed with chilled methanol to obtain 2.8 g compound of Formula (8B2). [0154] The above process can be repeated by using chiral diol sulfone of Formula (1a-A), (1a-C), (1a-D) for preparing the compound of Formula (8B1), (8B3) and (8B4) respectively by replacing the compound of Formula (1a-B).
The chemical industry reduces the impact on the environment during synthesis 147118-37-4, I believe this compound will play a more active role in future production and life.
Reference:
Patent; Dwivedi, Shriprakash Dhar; Patel, Dhimant Jasubhai; Rupapara, Mahesh Laljibhai; US2013/158263; (2013); A1;,
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