In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 137234-74-3, 4-Chloro-6-ethyl-5-fluoropyrimidine, other downstream synthetic routes, hurry up and to see.
137234-74-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 137234-74-3, name is 4-Chloro-6-ethyl-5-fluoropyrimidine. A new synthetic method of this compound is introduced below.
Preparation of 4-(4-chloro-phenylsulfanyi)-6-ethyI-5- flu oropy rimidin e 61.O g of 4-chloro-6-ethyl-5-fluoropyrimidine was added to 600 mNo. of acetonitrile, and 60.4 g of 4-chlorothiophenol was added thereto followed by lowering the temperature to 10 C . 66.1 mi of diisopropylethylamine was added to the resulting solution, and reacted for 2 hours while maintaining the temperature at room temperature. 100 mi of dichloromethane and 300 mi of water were added to the resulting mixture to separate layer, and the resulting aqueous mixture was extracted with 300 mi of dichloromethane. The organic layer was dried over magnesium sulfate, concentrated under a reduced pressure, and crystallized at 5 C in 305 mi of isopropanol and 122 mi of water to obtain the white title compound (85.6 g). Then, the filtrate was additionally concentrated under a reduced pressure, and crystallized at 5 C in 30 mi of isopropanol to obtain 12.3 g of the title compound (total: 97.9 g, total yield:%). 1H-NMR (300MHz, CDCl3) delta (ppm): 8.61 (IH), 7.47 (4H), 5.34 (IH), 2.04 (3H)
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 137234-74-3, 4-Chloro-6-ethyl-5-fluoropyrimidine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; HANMI PHARM. CO., LTD.; WO2009/20323; (2009); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia