The systematic study of pyrimidines began in 1884 with Pinner, who synthesized derivatives by condensing ethyl acetoacetate with amidines. Pinner first proposed the name “pyrimidin” in 1885. 2927-71-1, formula is C4HCl2FN2, Name is 2,4-Dichloro-5-fluoropyrimidine. The parent compound was first prepared by Gabriel and Colman in 1900, by conversion of barbituric acid to 2,4,6-trichloropyrimidine followed by reduction using zinc dust in hot water. Application of C4HCl2FN2.
Han, Zhengyu;Liu, Gang;Wang, Rui;Dong, Xiu-Qin;Zhang, Xumu research published 《 Highly efficient Ir-catalyzed asymmetric hydrogenation of benzoxazinones and derivatives with a Bronsted acid cocatalyst》, the research content is summarized as follows. The Ir-catalyzed highly efficient asym. hydrogenation of benzoxazinones I (R = H, 7-CH3, 6-Cl, etc.; R1 = H, 4-OCH3, 4-F, etc.) and derivatives II (R2 = H, CH3; R3 = C6H5, C2H5; n = 0, 1) was successfully developed with N-methylated ZhaoPhos as the ligand, which may display a new activation mode with a single anion-binding interaction among the substrate, cocatalyst Bronsted acid and ligand. This synthetic approach afforded a series of chiral dihydrobenzoxazinones III and derivatives IV with excellent results (>99% conversion, 88-96% yields, 91->99% ee, up to 40 500 TON). A key to success is the utilization of a strong Bronsted acid as the cocatalyst, such as hydrochloric acid, to form a possible single anion-binding interaction with the substrate and catalyst, which greatly contributed to the improvement of reactivity and enantioselectivity. Importantly, a creative and efficient synthetic route was developed to construct the important intermediate for the potential IgE/IgG receptor modulator through our catalytic methodol. system.
2927-71-1, 2,4-Dichloro-5-fluoropyrimidine is a useful research compound. Its molecular formula is C4HCl2FN2 and its molecular weight is 166.97 g/mol. The purity is usually 95%.
2,4-Dichloro-5-fluoropyrimidine is an aromatic hydrocarbon that has been shown to inhibit the growth of mouse tumor cells in vitro. It also inhibits the production of amines by reacting with industrial chemicals and sodium carbonate. This compound has potent inhibitory activity against autoimmune diseases and cytotoxic potency on mcf-7 cells. Furthermore, 2,4-Dichloro-5-fluoropyrimidine has been shown to have a chlorinating effect on cancer cells., Application of C4HCl2FN2
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia