Novacek, Alois; Fiedler, Pavel published the artcile< Nucleic acid components and their analogs. CXLI. Reactions of 5-bromo-6-azauracil>, Recommanded Product: 6-Bromo-1,2,4-triazine-3,5(2H,4H)-dione, the main research area is brominated azauracils alk reaction.
The reactions of 5-bromo-1,3-bis(2-cyanoethyl)-6-azauracil (I) and NaOMe or NaOEt or NaOBu was accompanied by a partial decyanoethylation to give the corresponding 5-alkoxy-1-(2-cyanoethyl)-6-azauracils. 5-Bromo-6-azauracil (II), 5-bromo-1-(2-cyanoethyl)-6-azauracil (III), and 5-bromo-3-benzyl-6-azauracil (IV) did not react with sodium alkoxides. 5-Bromo-1,3-dimethyl-6-azauracil refluxed with NaOEt in EtOH gave 5-ethoxy-1,3-dimethyl-6-azauracil. I heated in M NaOH at 90°, the mixture acidified with aqueous HCl, and refluxed with BzH in EtOH gave PhCH:NN(CH2CH2CN)CONHCH2CH2CN. II and IV reacted analogously to I but III was stable to aqueous NaOH. Treatment of 5-bromo-1,3-dibenzyl-6-azauracil with NaOEt in EtOH or with aqueous NaOH gave (by ring contraction) 2,4-dibenzyl-3,4-dihydro-1,2,4-triazol-3-one prepared also by refluxing PhCH:NN(CH2Ph)-CONHCH2Ph in HCO2H. PhCH:NN(CH2Ph)CONH2 refluxed in HCO2H gave PhCH:NN(CHO)CH2Ph. An analogous treatment of PhCH:NNHCONH2 gave (PhCH:N)2.
Collection of Czechoslovak Chemical Communications published new progress about 4956-05-2. 4956-05-2 belongs to class pyrimidines, and the molecular formula is C3H2BrN3O2, Recommanded Product: 6-Bromo-1,2,4-triazine-3,5(2H,4H)-dione.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia