Sodum, Rama S.; Klein, Robert S.; Otter, Brian A. published the artcile< Chemistry of 4-pyrimidinones: acetylation and ring-opening reactions>, Name: 5-Hydroxypyrimidin-4(3H)-one, the main research area is pyrimidinone acetylation ring cleavage.
4(3H)-Pyrimidinone (I), as well as its 5-acetoxy and 5-methoxy derivatives, undergoes selective acetylation at N-1 when treated with acetic anhydride. In the presence of water, these 1-acetylpyrimidines undergo spontaneous covalent hydration at C-2 and cleavage of the 1,2-bond to give crystalline cis-3-acetylamino-N-formylacrylamides, generally in good yield. In contrast, the 6-Me derivative of 4(3H)-pyrimidinone forms an equilibrium mixture of acetylated products that undergo the ring opening process to only a very limited extent, the major product (11%) being 3-formylamino-N-acetylacrylamide derivative formed via N-3 acetylation and cleavage of the 2,3-bond.
Journal of Heterocyclic Chemistry published new progress about Acetylation. 15837-41-9 belongs to class pyrimidines, and the molecular formula is C4H4N2O2, Name: 5-Hydroxypyrimidin-4(3H)-one.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia