《Amide-based inhibitors of p38α MAP kinase. Part 2: Design, synthesis and SAR of potent N-pyrimidyl amides》 was written by Tester, Richland; Tan, Xuefei; Luedtke, Gregory R.; Nashashibi, Imad; Schinzel, Kurt; Liang, Weiling; Jung, Joon; Dugar, Sundeep; Liclican, Albert; Tabora, Jocelyn; Levy, Daniel E.; Do, Steven. Quality Control of 2-Chloro-N-ethylpyrimidin-4-amine And the article was included in Bioorganic & Medicinal Chemistry Letters on April 15 ,2010. The article conveys some information:
Optimization of a tri-substituted N-pyridyl amide led to the discovery of a class of potent N-pyrimidyl amide based p38α MAP kinase inhibitors, e.g., I. Initial SAR studies led to the identification of 5-dihydrofuran I as an optimal hydrophobic group. Addnl. side chain modifications resulted in the introduction of hydrogen bond interactions. Through extensive SAR studies, analogs bearing free amino groups and alternatives to the parent (S)-α-Me benzyl moiety were identified. These compounds exhibited improved cellular activities and maintained balance between p38α and CYP3A4 inhibition. In addition to this study using 2-Chloro-N-ethylpyrimidin-4-amine, there are many other studies that have used 2-Chloro-N-ethylpyrimidin-4-amine(cas: 86443-51-8Quality Control of 2-Chloro-N-ethylpyrimidin-4-amine) was used in this study.
2-Chloro-N-ethylpyrimidin-4-amine(cas: 86443-51-8) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Quality Control of 2-Chloro-N-ethylpyrimidin-4-amine
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia