Application In Synthesis of 5,6-Dihydroxy-2-phenylpyrimidine-4-carboxylic acidOn October 18, 2004 ,《Active site inhibitors of HCV NS5B polymerase. The development and pharmacophore of 2-thienyl-5,6-dihydroxypyrimidine-4-carboxylic acid》 was published in Bioorganic & Medicinal Chemistry Letters. The article was written by Stansfield, Ian; Avolio, Salvatore; Colarusso, Stefania; Gennari, Nadia; Narjes, Frank; Pacini, Barbara; Ponzi, Simona; Harper, Steven. The article contains the following contents:
5,6-Dihydroxypyrimidine-4-carboxylic acids are a promising series of hepatitis C virus (HCV) NS5B polymerase inhibitors that bind at the active site of the enzyme. Here the authors report a simple 2-thienyl substituted analog that shows 10-fold improved activity over the original lead, and which allowed us to further delineate the key elements of the pharmacophore of this class of inhibitor. This work led to the identification of a trifluoromethyl acylsulfonamide group as a viable replacement for the C4 carboxylic acid in this series. In the part of experimental materials, we found many familiar compounds, such as 5,6-Dihydroxy-2-phenylpyrimidine-4-carboxylic acid(cas: 62222-38-2Application In Synthesis of 5,6-Dihydroxy-2-phenylpyrimidine-4-carboxylic acid)
5,6-Dihydroxy-2-phenylpyrimidine-4-carboxylic acid(cas: 62222-38-2) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics. Application In Synthesis of 5,6-Dihydroxy-2-phenylpyrimidine-4-carboxylic acid
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia