Yoon, Hyung; Galls, Alexandra; Rozema, Soren D.; Miller, Scott J. published the artcile< Atroposelective Desymmetrization of Resorcinol-Bearing Quinazolinones via Cu-Catalyzed C-O Bond Formation>, Formula: C7H7ClN2O2, the main research area is resorcinol quinazolinone preparation enantioselective; quinazolinone aryl bromide Ullmann coupling atroposelective desymmetrization copper catalyst.
Enantioselective Cu-catalyzed C-O cross coupling reactions yielding atropisomeric resorcinol-bearing quinazolinones have been developed. By utilizing a new guanidinylated dimeric peptidic ligand, products I (R = H, Br, R1 = H, NO2, CF3, R2 = Me, Et, R3 = H, Me, OMe, R4 = H, OMe, X = CH; R = R1 = R3 = R4 = H, R2 = Me, X = N) were generated in good yields with excellent stereocontrol. The transformation was readily scalable and a range of product derivatizations were performed.
Organic Letters published new progress about Aryl bromides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 89793-12-4 belongs to class pyrimidines, and the molecular formula is C7H7ClN2O2, Formula: C7H7ClN2O2.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia