Hin, Niyada; Duvall, Bridget; Ferraris, Dana; Alt, Jesse; Thomas, Ajit G.; Rais, Rana; Rojas, Camilo; Wu, Ying; Wozniak, Krystyna M.; Slusher, Barbara S.; Tsukamoto, Takashi published the artcile< 6-Hydroxy-1,2,4-triazine-3,5(2H,4H)-dione Derivatives as Novel D-Amino Acid Oxidase Inhibitors>, Quality Control of 4956-05-2, the main research area is hydroxytriazinedione preparation amino acid oxidase inhibitor.
A series of 2-substituted 6-hydroxy-1,2,4-triazine-3,5(2H,4H)-dione derivatives were synthesized as inhibitors of D-amino acid oxidase (DAAO). Many compounds in this series were found to be potent DAAO inhibitors, with IC50 values in the double-digit nanomolar range. The 6-hydroxy-1,2,4-triazine-3,5(2H,4H)-dione pharmacophore appears metabolically resistant to O-glucuronidation unlike other structurally related DAAO inhibitors. Among them, compound I was found to be selective over a number of targets and orally available in mice. Furthermore, oral coadministration of D-serine with I enhanced the plasma levels of D-serine in mice compared to the oral administration of D-serine alone, demonstrating its ability to serve as a pharmacoenhancer of D-serine.
Journal of Medicinal Chemistry published new progress about Alkylation. 4956-05-2 belongs to class pyrimidines, and the molecular formula is C3H2BrN3O2, Quality Control of 4956-05-2.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia