137234-74-3, Adding a certain compound to certain chemical reactions, such as: 137234-74-3, 4-Chloro-6-ethyl-5-fluoropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 137234-74-3, blongs to pyrimidines compound.
To the stirred solution of 4-chloro-6-ethyl-5-fluoro pyrimidine 1 (10 gm, 62.50 mmol) in CCl4 (150 mL) was added N-bromosuccinimide (12.7 gm, 71.35 mmol) and AIBnu (511 mg, 3.12 mmol). The reaction mixture was refluxed for 4 hrs at 75 C. The progress of the reaction was monitored by TLC. The reaction mixture then diluted with DCM (500 mL) and washed successively with water, sodium meta bisulphite (100 mL) solution, water and brine solution. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to obtain the bromide 2 as yellowish oily syrup (14 gm, 58.58 mmol, 94%). 1H NMR (CDCl3, 500 MHz): 2.10 (d, 3 H), 5.40 (q, 1 H), 8.80 (s, 1 H). Mass: 241(M++2)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,137234-74-3, its application will become more common.
Reference:
Patent; VIAMET PHARMACEUTICALS, INC.; WO2008/64311; (2008); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia