Jayne, Charles L.; Andreani, Teresa; Chan, Tin-Yau; Chelliah, Mariappan V.; Clasby, Martin C.; Dwyer, Michael; Eagen, Keith A.; Fried, Steve; Greenlee, William J.; Guo, Zhuyan; Hawes, Brian; Hruza, Alan; Ingram, Richard; Keertikar, Kartik M.; Neelamkavil, Santhosh; Reichert, Paul; Xia, Yan; Chackalamannil, Samuel published the artcile< Discovery of hydroxy pyrimidine Factor IXa inhibitors>, Recommanded Product: 4,6-Dichloro-5-methoxypyrimidine, the main research area is hydroxypyrimidine preparation Factor IXa inhibitor structure activity; Factor IXa; Factor IXa inhibition; Pyrimidine; Thrombosis.
The synthesis and structure activity relationship development of a pyrimidine series of heterocyclic Factor IXa inhibitors, I and II [R = Q, Q1, Q2, etc.], is described. Increased selectivity over Factor Xa inhibition was achieved through SAR expansion of the P1 element. Select compounds were evaluated in vivo to assess their plasma levels in rat.
Bioorganic & Medicinal Chemistry Letters published new progress about Blood coagulation factor inhibitors (factor IXa). 5018-38-2 belongs to class pyrimidines, and the molecular formula is C5H4Cl2N2O, Recommanded Product: 4,6-Dichloro-5-methoxypyrimidine.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia