Le, Phuong T.; Richardson, Paul F.; Sach, Neal W.; Xin, Shuibo; Ren, Shijian; Xiao, Jiezhan; Xue, Liangliang published the artcile< Development of a Scalable Synthesis of 4-Aminopyrimidin-5-ol, a Versatile Intermediate>, SDS of cas: 5018-38-2, the main research area is aminopyrimidinol preparation green chem.
A robust process for the preparation of multigram quantities of 4-aminopyrimidin-5-ol in good yield from an inexpensive and readily available 4,6-dichloro-5-methoxypyrimidine starting material is described. An initial evaluation of the reported literature route for this material utilizing a de novo pyrimidine synthesis provided safety concerns over the scalability of several intermediates. In addition, a number of steps proceeded in mediocre yield, and involved chromatog. separations for the desired products. The newly developed route mitigates the safety concerns, reduces the number of steps from five to three, avoids column chromatog., leads to an 8-fold improvement in yield, and utilizes reagents, which are recognized to be more environmentally benign.
Organic Process Research & Development published new progress about Green chemistry. 5018-38-2 belongs to class pyrimidines, and the molecular formula is C5H4Cl2N2O, SDS of cas: 5018-38-2.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia