Reddy, L. Srikanth; Naik, B. Eswar published the artcile< Design, synthesis and characterization of novel thieno[2,3-d]pyrimidines for anti-bacterial and anti-fungal screening>, Quality Control of 18740-39-1, the main research area is thiomorpholinothieno pyrimidine preparation antibacterial antifungal.
A series of novel 4-Substituted and different substituted heterocyclic-N-(2-thiomorpholinothieno[2,3-d]pyrimidin-4-yl)benzamide derivatives I (R = Ph, thiophen-2-yl, 2,5-difluorophenyl, etc.) was synthesized by a facile five-step procedure that afforded advantages of mild reaction conditions, simple protocol and good yields. The final compounds were screened for their antibacterial activity against Staphylococcus aureus (S. aureus) and Bacillus subtilis (B. subtilis) from Gram pos. group of bacteria and Pseudomonas aeruginosa (P. aeruginosa) and Escherichia coli (E. coli) from Gram neg. group of bacteria and antifungal activity against Aspergillus niger (A. niger) and Candida albicans (C. albicans). Anti-bacterial and anti-fungal activities were evaluated and compared with the standard drugs Such as Amoxicillin and Fluconazole from anti-bacterial and antifungal activity screening results, and it has been observed that compounds I (R = thiophen-2-yl, 1-benzothiophen-2-yl, 2,5-difluorophenyl, 4-(trifluoromethyl)phenyl) possess good activity.
Pharma Innovation published new progress about Antibacterial agents. 18740-39-1 belongs to class pyrimidines, and the molecular formula is C6H2Cl2N2S, Quality Control of 18740-39-1.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia