Gurunadham, G.; Madhusudhan, Raju R. published the article 《New and alternate synthesis of lacosamide with chemoenzymatic method》. Keywords: enzymic resolution racemic lacosamide; lacosamide enantiopure preparation.They researched the compound: 2-Bromo-3-methoxypropanoic acid( cas:65090-78-0 ).Formula: C4H7BrO3. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:65090-78-0) here.
Lacosamide [(R)-2-acetamido-N-benzyl-3-methoxy propionamide] 5 is a novel antiepileptic drug. Lacosamide was prepared by a chem. method with enzymic resolution of racemic lacosamide. Herein is reported an expedient four-steps enantioselective synthesis of lacosamide 5 beginning with Me 2,3-dibromo propionate 1. A new resolution process catalyzed by Novozyme 435. The products were obtained in very good yields and in a state of high purity. All the newly synthesized compounds (2-5) were characterized by their spectral (IR, 1H NMR, C13 NMR and MS) data.
Compounds in my other articles are similar to this one(2-Bromo-3-methoxypropanoic acid)Formula: C4H7BrO3, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.
Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia