In an article, author is Fang, Hui-Lin, once mentioned the application of 873-83-6, COA of Formula: C4H5N3O2, Name is 6-Aminopyrimidine-2,4(1H,3H)-dione, molecular formula is C4H5N3O2, molecular weight is 127.1, MDL number is MFCD00006071, category is pyrimidines. Now introduce a scientific discovery about this category.
Domino beta-C-H Functionalization and [3+2] Cycloaddition for Efficient Synthesis of Diverse Spiro and Polycyclic Compounds
The acetic acid catalyzed three-component reaction of pyrrolidine, aromatic aldehydes and 4-arylidene-5-methyl-2-phenylpyrazol-3-one in refluxing toluene gave functionalized 7 ‘-(E)-benzylidenespiro[pyrazole-4,1 ‘-pyrrolizines] in good yields and with high diastereoselectivity. The similar reaction with 2-arylidene-N,N’-dimethylbarbiturates resulted in mixture of Z/E-isomers of 7 ‘- arylidenespiro[pyrimidine-5,1 ‘-pyrrolizines] in good yields. However, the three-component with N-phenylmaleimides and sequential oxidation with DDQ reaction gave 8-(E)-arylidenedihydropyrrolo[3,4-a]pyrrolizines in satisfactory yields. The reaction mechanism included sequential beta-C-H functionalization of pyrrolidine, generation of conjugated azomethine ylides, and sequential [3+2] cycloaddition with active alkenes.
If you are interested in 873-83-6, you can contact me at any time and look forward to more communication. COA of Formula: C4H5N3O2.
Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia