Synthetic Route of 10070-92-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 10070-92-5, name is Pyrimidine-5-carbaldehyde. This compound has unique chemical properties. The synthetic route is as follows.
To a 10-mL round-bottom flask containing crude amine 21 (1 eq., 0.834 mmol, 248 mg) was added 5-formylpyrimidine (2.1 eq., 1.75 mmol, 189 mg), Na(OAc)3BH (2.5 eq., 2.09 mmol, 442 mg) and a stir bar. The flask was sealed with a rubber septum, evacuated under high vacuum, and backfilled with argon. The contents were suspended in anhydrous 1 ,2-dichloroethane (5 mL), and the reaction was stirred vigorously at room temperature overnight. The reaction mixture was quenched with 1 M disodium citrate (1 mL) for ~ 15 minutes, followed by extraction with dichloromethane (3 x 10 mL). The combined organic layers were dried over Na2S04, filtered, and concentrated to an amber-colored oil. The oily residue was purified by column chromatography (silica gel) using 7:3 acetone:DCM as the eluent. The pure column product (pale yellow oil) was crystallized by the addition of MTBE, followed by recrystallization from boiling MTBExyclohexane to afford 4a as an off-white solid. Yield: 54 mg (0.112 mmol, 13%). FontWeight=”Bold” FontSize=”10″ H NMR (CDCb, 400 MHz) delta 3.82 (s, 4H), 3.84 (s, 2H), 3.86 (s, 3H), 6.97 (d, J= 8.8 Hz, 2H), 7.30 (dd, J= 7.7, 0.8 Hz, 1H), 7.60 (d, J= 8.8 Hz, 2H), 7.79 (t, J = 7.8 Hz, 1H), 7.99 (s, 1H), 8.09 (dd, J= 7.8, 0.8 Hz, 1H), 8.82 (s, 4H), 9.17 (s, 2H). 13C NMR (CDCb, 100 MHz) delta 53.1, 55.4, 58.1, 114.6, 118.1, 123.5, 124.0, 128.1, 131.7, 137.7, 138.7, 141.8, 151.3, 157.6, 158.1, 160.0, 166.8. EI-MS m/z 481 ([M]+, 3%), 282 (100%,). EI- HRMS m/z calc’d for C26H23N7OS 481.1685, found 481.1676.
According to the analysis of related databases, 10070-92-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GEORGIA TECH RESEARCH CORPORATION; FAHRNI, Christoph J.; MCCALLUM, Adam M.; MORGAN, Michael Thomas; (109 pag.)WO2018/231843; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia