The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1032452-86-0, name is 3-(2-Chloropyrimidin-4-yl)-1-methyl-1H-indole. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 1032452-86-0
Under nitrogen protection,200 mg of (4-fluoro-2-methoxy-5-nitrophenyl) -methylamine was added to the reaction flask in this order(1.0 mmol),244 mg of 3- (2-chloropyrimidin-4-yl) -1-methylindole (CAS 1032452-86-0, 1.0 mmol), 207 mg of p-toluenesulfonic acid monohydrate -pentanol.The mixture was stirred at 105 C for two hours until TLC showed the reaction was complete.The reaction was cooled to room temperature and the resulting solid was collected by filtration;The filtrate was cooled with an ice water bath,The resulting solid was collected by filtration.Two batches of solid were combined and washed with acetonitrile,367 mg of a gray solid was obtained,Yield 90%.
With the rapid development of chemical substances, we look forward to future research findings about 1032452-86-0.
Reference:
Patent; Nantong Yin Nuowei Pharmaceutical Technology Co., Ltd.; Lanzhou University The Second Hospital; Han Zhijian; Bian Hongzhu; (9 pag.)CN107266426; (2017); A;,
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