The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1193-21-1, name is 4,6-Dichloropyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 4,6-Dichloropyrimidine
To 398 4,6-dichloropyrimidine (131 g, 879 mmol), 399 4-(trifluoromethoxy)phenylboronic acid (200g, 970 mol), 106 potassium carbonate (244 g, 1.77 mol) and 266 tetrakis(triphenylphosphine)palladium(0) (21.5 g, 18.6 mmol) were added 115 1,4-dioxane (3.0 L) and 52 water (200 mL) and the mixturewas stirred at 105 C. for 6 hr. The insoluble material was filtered off, the filtrate was concentrated underreduced pressure and the obtained residue was purified by silica gel column chromatography (petroleumether/ethyl acetate) to give the 400 title compound ( 78.0 g , 284 mmol, 32%). MS (ESI) m/z 275 (M+H)+ 1H NMR (400 MHz, CDCl3) delta 9.04 (s, 1H), 8.13 (d, J=8.6 Hz, 2H), 7.73 (s, 1H), 7.36 (d, J=8.6 Hz, 2H).
With the rapid development of chemical substances, we look forward to future research findings about 1193-21-1.
Reference:
Patent; EA PHARMA CO., LTD.; KOBAYASHI, Kaori; SUZUKI, Tamotsu; KAWAHIRA, Mizuki; FUJII, Tomohiro; SUGIKI, Masayuki; OHSUMI, Koji; OKUZUMI, Tatsuya; (285 pag.)US2016/332999; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
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