A new synthetic route of 1235450-86-8

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1235450-86-8, 5-Bromo-2-ethylpyrimidine-4-carboxylic acid, and friends who are interested can also refer to it.

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1235450-86-8, name is 5-Bromo-2-ethylpyrimidine-4-carboxylic acid, molecular formula is C7H7BrN2O2, molecular weight is 231.05, as common compound, the synthetic route is as follows.Quality Control of 5-Bromo-2-ethylpyrimidine-4-carboxylic acid

A mixture of 5-Bromo-2-ethylpyrimidine-4-carboxylic acid (5.6 g, 24.3 mmol) in xylene (50 mL) was refluxed for 2 h. After cooling, the mixture was applied directly to a silica column, which was eluted with petroleum ether, then ethyl acetate in petroleum ether (5%) to give compound 0601-121 (1.7 g, 38%) as a yellow liquid. 1H NMR (400 MHz, DMSO-d6): 1.26 (t, J=7.6 Hz, 3H), 2.87 (q, J=7.6 Hz, 2H), 8.90 (s, 2H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1235450-86-8, 5-Bromo-2-ethylpyrimidine-4-carboxylic acid, and friends who are interested can also refer to it.

Reference:
Patent; Curis, Inc.; Bao, Rudi; Lai, Chengjung; Qian, Changgeng; US2013/102595; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia