HPLC of Formula: 1260667-65-9. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 5-Chloro-4-iodopyridin-2-amine, is researched, Molecular C5H4ClIN2, CAS is 1260667-65-9, about From Milligram to Kilogram Manufacture of AZD4573: Making It Possible by Application of Enzyme-, Iridium-, and Palladium-Catalyzed Key Transformations. Author is Karlsson, Staffan; Benson, Helen; Cook, Calum; Currie, Gordon; Dubiez, Jerome; Emtenaes, Hans; Hawkins, Janet; Meadows, Rebecca; Smith, Peter D.; Varnes, Jeffrey.
With the first generation medicinal chem. synthesis as a starting point, herein process development of AZD4573, an oncol. drug candidate was described. In addition to improved yields and removal of chromatog. steps, other factors such as availability of starting materials as well as safety of the chem. involved were addressed. With several steps involving volatile, reactive, and non-UV active materials, reaction optimization was facilitated by implementing off-line 1H NMR anal. of crude mixtures Key transformations targeted for process development included a Wolff-Kishner reduction, an iridium-catalyzed borylation, and enzymic resolution of a racemic amino-ester.
There is still a lot of research devoted to this compound(SMILES：NC1=NC=C(Cl)C(I)=C1)HPLC of Formula: 1260667-65-9, and with the development of science, more effects of this compound(1260667-65-9) can be discovered.
Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia