Application of 14394-56-0, Adding some certain compound to certain chemical reactions, such as: 14394-56-0, name is 4-Amino-6-chloro-5-methylpyrimidine,molecular formula is C5H6ClN3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 14394-56-0.
The compound 6-chloro-5-methylpyrimidin-4-amine 48a (100 mg, 0.700 mmol), cyclopropylcarbonyl chloride (87 mg,0.839 mmol), pyridine (3 mL) and tetrahydrofuran (3 mL) were combined.The mixture was heated to 60 C and stirred for 16 hours.This mixture was diluted with 20 ml of water and extracted with ethyl acetate (20 mL¡Á2).The combined organic phases were washed with brine (20 mL¡Á2).The organic phase is dried over anhydrous sodium sulfate, and the desiccant is removed by filtration.Decompressing under reduced pressure to obtain a crude product,The residue was purified by preparative silica gel ( petroleum ether / ethyl acetate = 4:1).The target product N-(6-chloro-5-methylpyrimidin-4-yl)cyclopropanecarboxamide 48b (40 mg,0.190 mmol, white solid). Yield: 27%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 14394-56-0, 4-Amino-6-chloro-5-methylpyrimidine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Nanjing Tianyinjianhua Pharmaceutical Technology Co., Ltd.; Kong Xianglong; Zhou Chao; Zheng Zhixiang; (105 pag.)CN109020957; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia