147118-40-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 147118-40-9, name is Rosuvastatin methyl ester. This compound has unique chemical properties. The synthetic route is as follows.
To a stirred solution of 16 (149 mg, 0.3 mmol) in MeOH (2 mL) at 0 ¡ãC was added NaOH (0.36 mL, 1.0 M, 0.36 mmol), then reacted at 0 ¡ãC for 1 h before being added the solution of CaCl2 (1.5 mL, 0.2 M, 0.3 mmol). The mixture was stirred at 20 ¡ãC for 0.5 h before filtrated the resulting white slurry, washed, and dried in vacuum to afford 1 (133 mg, 89percent) as a white powder; mp 145-149 ¡ãC, lit. 17 mp 145-150 ¡ãC; [a]D14.5 7.3 (c 0.5, CHCl3); 1H NMR (400 MHz, CDCl3) d 1.20 (d, J=6.0 Hz, 6H), 1.28-1.36 (m, 1H), 1.47-1.54 (m, 1H), 1.97-2.03 (m, 1H), 2.12-2.16 (m, 1H), 3.36-3.43 (m, 1H), 3.43 (s,3H), 3.54 (s, 3H), 3.76 (m, 1H), 4.20 (m, 1H), 5.52 (dd, J=5.6, 16.0 Hz, 1H), 6.50 (d, J=16.0 Hz, 1H), 7.27 (t, J=8.4 Hz, 2H), 7.70 (dd, J=6.0,8.0 Hz, 2H); MS (ESI): m/z 482 (acid, MH), 504 (acid, MNa); IR (KBr): 3376, 2973, 2931, 2875, 1604, 1548, 1442, 1073, 968, 844, 776 cm-1.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 147118-40-9, Rosuvastatin methyl ester.
Reference:
Article; Chen, Xiaofei; Xiong, Fangjun; Zheng, Chen; Li, Jie; Chen, Fener; Tetrahedron; vol. 70; 35; (2014); p. 5794 – 5799;,
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