Related Products of 16019-33-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.16019-33-3, name is 2-(4,6-Dichloropyrimidin-5-yl)acetaldehyde, molecular formula is C6H4Cl2N2O, molecular weight is 191.02, as common compound, the synthetic route is as follows.
To the stirred solution of (R)-3-amino-pyrrolidine-1 -carboxylic acid tert-butyl ester (CAS 147081-49-0; 4.68 g, 25.1 mmol, 1.0 eq) and EtOH (50 mL) was added N,N- diisopropylamine (4.30 mL, 25.1 mmol, 1.0 eq) and 4,6-dichloro-pyrimidin-5-yl)-acetaldehyde (CAS 16019-33-3; 4.80 g, 25.1 mmol,). The reaction mixture was stirred for 8h at reflux temperature and then concentrated. The residue was dissolved in THF (37.5 mL) and HCI 4M (12.5 mL) was added at 0 C and stirred for an additional hour at 0 C. The reaction mixture was partitioned between Na2C03 1 M and EtOAc. The combined organic layers were washed with brine, dried (Na2S0 ), filtered and concentrated. The residue was purified by silica gel column chromatography (EtOAc – nheptane 1 :1 ) to afford 6.70 g of the title compound as a yellow oil: HPLC-MS: M+H = 323.4 (Rt = 1.27) (Method X): TLC; R, = 0.19 (EtOAc – n heptane 1 :2).
Statistics shows that 16019-33-3 is playing an increasingly important role. we look forward to future research findings about 2-(4,6-Dichloropyrimidin-5-yl)acetaldehyde.
Reference:
Patent; NOVARTIS AG; IRM LLC; CHEN, Bei; FAIRHURST, Robin, Alec; FLOERSHEIMER, Andreas; FURET, Pascal; GUAGNANO, Vito; JIANG, Songchun; LU, Wenshuo; MARSILJE, Thomas, H.; MCCARTHY, Clive; MICHELLYS, Pierre-Yves; STAUFFER, Frederic; STUTZ, Stefan; VAUPEL, Andrea; WO2011/29915; (2011); A1;,
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