The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 16462-27-4, name is 2,4-Diaminopyrimidine-5-carbonitrile. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C5H5N5
[0132] To a solution of 2,4-diaminopyrirnidine-5-carbonitrile (145 mg, 1.07 mmol) in 1,4- dioxane (20 mL) was added l-(2-(3-bromophenoxy)ethyl)rhoyrrolidine (290 mg, 1.07 mmol), Cs2CO3 (1.43 g, 4.4 mmol), Pd2(dba)3 (92 mg, 0.1 mmol), and 4,5-bis(diphenylphosphino)- 9,9-dimethyxanthene (Xant Phos, 174 mg, 0.3 mmol). The mixture was heated under reflux for 4 h under Ar. The solid was filtered off and the filtrate washed with brine (1 x 100 mL). The organic solution was separated and dried (Na2SO4). The solvent was removed until 5 mL and hexane (50 mL) was added, the solid was collected by filtration. The crude product was purified by HPLC and afforded the title intermediate 22 (55 mg, 16%).
With the rapid development of chemical substances, we look forward to future research findings about 16462-27-4.
Reference:
Patent; TARGEGEN, INC.; WO2007/53452; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia