The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1753-50-0, name is 2-Chloropyrimidine-5-carbonitrile. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 1753-50-0
To a stirred solution of 2-chloropyrimidine-5-carbonitrile (AF, 3.95 g, 28 mmol) and compound LH (7.0 g, 21.8 mmol) in EtOH (50 mL), DIPEA (18.5 mL, 109 mmol) was added and the reaction was stirred at 90C for 16 h. The progress of the reaction was monitored by TLC. After completion of the reaction, the reaction mixture was concentrated under reduced pressure. The crude product was purified by silica gel column chromatography using 20% EtOAc/hexane to afford racemic compound LI (8.5 g, 91.9%) as an off white solid. 1H NMR (400 MHz, DMSO-d6): _ 8.79 (d, = 8.4 Hz, 1H), 8.67 (d, = 9.6 Hz, 2H), 7.46 (d, = 8.4 Hz, 2H), 7.30 (d, = 7.6 Hz, 2H), 6.99 (m, 1H), 5.22- 5.17 (m, 1H), 3.36 -3.29 (m, 2H), 1.29 (s, 9H). LC-MS: m/z 424.10 [M+H]+; HPLC Purity: 98.60%.
With the rapid development of chemical substances, we look forward to future research findings about 1753-50-0.
Reference:
Patent; VPS-3, INC.; YATES, Christopher, M.; (397 pag.)WO2018/165520; (2018); A1;,
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