Adding a certain compound to certain chemical reactions, such as: 1780-33-2, 4,6-Dichloro-2,5-dimethylpyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 1780-33-2, blongs to pyrimidines compound. SDS of cas: 1780-33-2
Two solutions, one with the aryl halide (0.56 mmol, 1.0 equivalent) in THF- H2O (2.5 mL, 3:2 v/v) and one with phenol (0.84 mmol, 1.5 equivalent) and NaOH (0.84 mmol, 1.5 equivalent) in THF-H2O (2.5 mL, 3:2 v/v) were prepared and then introduced into Asia microfluidic reactor by Pump A & B (see, e.g., Figure 4). The mixture was pumped through a preheated 1 mL glass microfluidic reactor at a predetermined flow rate to achieve the desired residence time. The crude product was collected in a flask and extracted with ethyl acetate. The organic phase was combined, dried MgSO4 and concentrated under reduced pressure. The isolated crude product was purified using a prepacked silica cartridge on a Teledyne CombiFlash Rf 200 instrument. Fractions corresponding to the product peak were combined and concentrated using rotavap to afford 1 as white solid (135 mg, 87percent).1H NMR (CDC13) delta2.08 (s, 3H), 2.36 (s, 3H), 2.41 (s, 3H), 3.79 (s, 3H), 6.72- 6.79 (m, 2H) and 6.94 (d, J= 8.4 Hz, 1H); 13C NMR (CDC13) delta11.6, 16.7, 25.5, 55.6, 111.9, 113.0, 116.2, 122.6, 131.3, 144.9, 157.1, 160.1, 165.2 and 168.1; mass spectrum (APCI), m/z calcd for C14H16C1N202 (M+H)+ 279.0895, found 279.0888.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1780-33-2, 4,6-Dichloro-2,5-dimethylpyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; ALAM, Mohammad Parvez; JOHN, Varghese; JOGODZINSKA, Barabara; (120 pag.)WO2018/48953; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia