Related Products of 3993-78-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3993-78-0, name is 2-Amino-4-chloropyrimidine, molecular formula is C4H4ClN3, molecular weight is 129.55, as common compound, the synthetic route is as follows.
General procedure: To a solution of compound 6l (1.40 g, 6.85 mmol) and 2,4-dichoropyrimidine (1.53 g, 10.28 mmol) in anhydrous EtOH (20 ml) was added DIEA (1.92 ml, 20.55 mmol) with dropwised manner, and the reaction was stirred at 40 C for 3 h. The mixture was evaporated to dryness and then partitioned between water and CH2Cl2. The organic layer was dried over anhydrous magnesium sulfate, filtered, and concentrated. The crude product was purified by column chromatography to afford 7l (2.03 g, 94%) as a white solid.
Statistics shows that 3993-78-0 is playing an increasingly important role. we look forward to future research findings about 2-Amino-4-chloropyrimidine.
Reference:
Article; Zhou, Wenbo; Huang, Anling; Zhang, Yong; Lin, Qingxiang; Guo, Weikai; You, Zihua; Yi, Zhengfang; Liu, Mingyao; Chen, Yihua; European Journal of Medicinal Chemistry; vol. 96; (2015); p. 269 – 280;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia