The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 37482-64-7, name is 2-Chloro-4-ethoxy-6-methylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Safety of 2-Chloro-4-ethoxy-6-methylpyrimidine
To a round bottom flask containing 600 mg (3.48 mmol) of 2-chloro-4-ethoxy-6-methylpyrimidine, 489 mg (5.22 mmol) of azetidine hydrochloride, 131 mg (0.69 mmol) of CuI, 164 mg (0.69 mmol) of 3,4,7,8-tetramethyl-1,10-phenanthroline and 2.83 g (8.70 mmol) of Cs2CO3 was added 15 mL of dry, degassed DMF. The reaction mixture was stirred at 50 C for 3 h. The cooled reaction mixture was filtered through Celite and the Celite pad was washed with portions of CH2Cl2. The combined organic phase was washed with water and then with brine, dried (MgSO4) and concentrated under diminished pressure. The residue was purified by flash chromatography on a silica gel column (15 * 3 cm). Elution with 19:1 hexane/EtOAc followed by 9:1 hexane/EtOAc afforded 18 as a colorless solid: yield 565 mg (84%); mp 42-43 C; silica gel TLC Rf 0.29 (3:2 hexane/EtOAc); 1H NMR (CDCl3) delta 1.24 (t, 3H, J = 7.2 Hz), 2.16 (s, 3H), 2.20 (quint, 2H, J = 7.6 Hz), 4.01 (t, 4H, J = 7.6 Hz), 4.20 (q, 2H, J = 7.2 Hz) and 5.73 (s, 1H); 13C NMR (CDCl3) delta 14.4, 16.1, 23.9, 49.9, 61.2, 95.0, 163.0, 167.7 and 170.1; mass spectrum (APCI), m/z 194.1289 (M+H)+ (C10H16N3O requires m/z 194.1293).
With the rapid development of chemical substances, we look forward to future research findings about 37482-64-7.
Reference:
Article; Chevalier, Arnaud; Alam, Mohammad Parvez; Khdour, Omar M.; Schmierer, Margaret; Arce, Pablo M.; Cripe, Cameron D.; Hecht, Sidney M.; Bioorganic and Medicinal Chemistry; vol. 24; 21; (2016); p. 5206 – 5220;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia