A new synthetic route of 2-Chloro-5-fluoropyrimidine

According to the analysis of related databases, 62802-42-0, the application of this compound in the production field has become more and more popular.

Synthetic Route of 62802-42-0, Adding some certain compound to certain chemical reactions, such as: 62802-42-0, name is 2-Chloro-5-fluoropyrimidine,molecular formula is C4H2ClFN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 62802-42-0.

2-Chloro-5-fluoropyrimidine (541mg, 4.0mmol) was added to suspension of N (800mg, 3.72mmol) and potassium carbonate (l .Og, 7.44mmol) in diglyme(15mL), the resulting mixture was stirred at 100 C for 6 h. On completion the mixture was cooled to 0C and filtered, the solid was taken in water (50mL) and stirred for 30 mins. The suspension was filtered, the solid cake was washed with water (50mL), pet ether (15mL) and dried under vacuum to afford l .Og (86%) of P as yellow color solid. [TLC system:Ethyl acetate:pet ether (3 :7).-R/value:0.701.

According to the analysis of related databases, 62802-42-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; F2G LIMITED; SIBLEY, Graham Edward Morris; LAW, Derek; OLIVER, Jason David; BIRCH, Michael; (76 pag.)WO2016/79536; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia