A new synthetic route of 213265-83-9

Statistics shows that 213265-83-9 is playing an increasingly important role. we look forward to future research findings about 4,6-Dichloro-5-fluoropyrimidine.

213265-83-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 213265-83-9, name is 4,6-Dichloro-5-fluoropyrimidine, the common compound, a new synthetic route is introduced below.

To a stirred solution of 20.2 (120 mg, 0.000722 mol) in n-butanol (0.5 mL) was added NH4OH (1 mL). The reaction mixture was heated at 90 C. for 2.5 hr in a sealed tube. The reaction mixture was cooled to 0 C., and the resulting solid was filtered and dried under vacuum to give 20.3 (60 mg, 57%). 1H-NMR (DMSO-d6 500 MHz): delta 8.03 (s, 1H), 7.60 (s, 2H); m/z: 148 [M+1]+.

Statistics shows that 213265-83-9 is playing an increasingly important role. we look forward to future research findings about 4,6-Dichloro-5-fluoropyrimidine.

Reference:
Patent; Sunesis Pharmaceuticals, Inc.; US2009/36419; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia