Reference of 10457-14-4 ,Some common heterocyclic compound, 10457-14-4, molecular formula is C10H20N2O2Si2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
TMS-protected uracil was dissolved in dry MeCN (10 ml) under nitrogen and TMSOTf (7.12 g,32 mmol) was added dropwise. When the reaction mixture was added with stirring, the mixture was clarified and compound V (1 g, 4 mmol ) In MeCN (2 ml) wasadded dropwise to the above reaction mixture. The mixture was stirred at 40 C for 10 h. TLC Compound V was quenched with ice water, filtered through celite and washed withDCM (30 ml * 2 times) The filter cake was separated and the organic phase was washed with NaCl (sat), dried over anhydrous sodium sulfate and the crude product was spin-dried directlyfor the next step.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,10457-14-4, its application will become more common.
Reference:
Patent; Shanghai Hongbozhiyuan Pharmaceutical Co., Ltd.; Li Dafeng; Chen Ping; (15 pag.)CN107200757; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia