A new synthetic route of 2,4-Dichloro-5-iodopyrimidine

The chemical industry reduces the impact on the environment during synthesis 13544-44-0, I believe this compound will play a more active role in future production and life.

Reference of 13544-44-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.13544-44-0, name is 2,4-Dichloro-5-iodopyrimidine, molecular formula is C4HCl2IN2, molecular weight is 274.88, as common compound, the synthetic route is as follows.

S-62 (20 g) was converted to S-63 by reaction S-63b and S-62 in the presence of NaHCOs in DMA at 80 C for 12h. After purification, 12 g of S-63 was obtained .

The chemical industry reduces the impact on the environment during synthesis 13544-44-0, I believe this compound will play a more active role in future production and life.

Reference:
Patent; G1 THERAPEUTICS, INC.; STRUM, Jay, Copeland; JUNG, David; (207 pag.)WO2019/136244; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia