Application of 1240390-28-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1240390-28-6, name is 2,4-Dichloropyrimidine-5-carboxylic acid amide. This compound has unique chemical properties. The synthetic route is as follows.
4-(Bicyclo [1.1.1] pentan-l-ylamino)-2-chloropyrimidine-5-carboxamide : A mixture of 2,4-dichloro-pyrimidine-5-carboxamide (2 g), bicyclo[l.l.l]pentan-l-amine hydrochloride (1.18 g), sodium bicarbonate (1.75 g), and NMP (10 mL) was stirred at 25 C for 24 h. Water (10 mL) was charged maintaining the reaction temperature less than 30 C, and the mixture was stirred at 25 C for 2 h. The suspension was filtered, and washed with NMP: water (1 : 1 10 mL), then water (2X10 mL), and dried in a vacuum oven at 40 C with nitrogen sweep to give 4-(bicyclo[l .l . l]pentan-l-ylamino)-2-chloropyrimidine-5 -carboxamide as a white solid (1.97 g, 83 %yield). 1H NMR (DMSO-d6) delta 2.14 (s, 6H), 2.51-2.53 (m, 1H), 7.76 (br. s., 1H), 8.23 (br. s., 1H), 8.60 (s, 1H), 9.57 (s, 1H).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1240390-28-6, 2,4-Dichloropyrimidine-5-carboxylic acid amide.
Reference:
Patent; SIGNAL PHARMACEUTICALS, LLC; FERRETTI, Antonio Christian; MAN, Hon-Wah; MUSLEHIDDINOGLU, Jale; XU, Jean; YONG, Kelvin Hin-yeong; BEAUCHAMPS, Marie Georges; KOTHARE, Mohit Atul; ZHOU, Nanfei; BOERSEN, Nathan Andrew; LI, Ying; HILGRAF, Robert; NAGY, Mark A.; ZOU, Daozhong; HUANG, Lianfeng; WO2015/116755; (2015); A2;,
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