Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 5750-74-3, name is 2,5-Dichloro-4-methoxypyrimidine. A new synthetic method of this compound is introduced below., Product Details of 5750-74-3
A solution of (2S,4R)-tert-butyl 4-amino-2-methylpyrrolidine-l-carboxylate (200 mg, 1.0 mmol), 2,5-dichloro-4-methoxypyrimidine (358 mg. 2.0 mmol) and K2C03 (226 mg, 2.0 mmol) in DMSO (10 mL) was stirred at RT for 2 hrs. The reaction mixture was diluted with water (30 mL) and extracted with EA (20 mL*3). The combined organic layers were washed with water (50 mL) and brine (50 mL), dried over Na2S04, filtered and concentrated in vacuo. The residue was purified by silica gel chromatography (PE:EA = 1 : 1) to afford (2S,4R)-tert-butyl 4-((5-chloro-4- methoxypyrimidin-2-yl)amino)-2-methylpyrrolidine-l-carboxylate (100 mg, 30%) as a white solid. [M+H] Calc?d for CisH^ClN^s, 343.1; Found, 343.1
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Reference:
Patent; KINNATE BIOPHARMA INC.; KANOUNI, Toufike; ARNOLD, Lee D.; KALDOR, Stephen W.; MURPHY, Eric A.; TYHONAS, John; (0 pag.)WO2020/6497; (2020); A1;,
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