Related Products of 130049-82-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 130049-82-0, name is 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidine-4-one. This compound has unique chemical properties. The synthetic route is as follows.
To a 250 ml three-necked flask, ethanol (100 mL), HW03603-4 (24.2 g, 46 mmol) and 6N HCl or trifluoroacetic acid (50 mL) were sequentially added at room temperature. Then, the reaction system was stirred at room temperature overnight. Depressurization to give a white solid HW03603-5 (about 20g,Yield 100%). Used directly in the next step. Preparation of target compound HW03603: Steps 1-4 of Reference Example 1 Preparation of target compound HW03603: Steps 1-4 of Reference Example 1Add to the 100 ml three-necked bottle at room temperature:Methanol (50 mL), HW03603-5 (4.6 g, 10.8 mmol),HW036-6 (2.62g, 10.8mmol)And N,N-diisopropylethylamine (4.2 g, 32.4 mmol).Then, the reaction system was heated to reflux and stirred overnight.The solvent was evaporated to dryness The organic phase was combined, washed with saturated brine, dried over anhydrous sodium sulfate and filtered.Depressurization to obtain a solid,Recrystallization from methanol gave a white solid HW03603 (3.35 g, yield 49%).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 130049-82-0, 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidine-4-one.
Reference:
Patent; Shanghai Kezhen Pharmaceutical Technology Co., Ltd.; Dong Huanwen; Zhang Lurong; (55 pag.)CN109748914; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia