Application of 330786-24-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 330786-24-8, name is 3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine. This compound has unique chemical properties. The synthetic route is as follows.
The 3- (4-phenoxyphenyl) -1H-pyrazolo [3,4-d]pyrimidin-4-amine(compound 2a)(2.12g,7mmol), 3-hydroxypiperidine-1- tert-Butyl formate(1.55g,7.7mmol), Triphenylphosphine(2.75g,10.5mmol)and Azobisisobutyronitrile (2.12g,10.5mmol) dissolved in THF (250ml), keep thereaction at room temperature for 12h(TLC thin layer chromatography monitoringreaction is complete or not). After the completion of the reaction , solventwas recovered under reduced pressure. into the remaining reaction mixture added100 ethyl acetate, organic layer was extracted three times with Saturatedsodium carbonate solution 100ml*3, organic phases were combined, washed oncewith saturated sodium chloride and dried over anhydrous sodium sulfate. The solvent was recovered under reducedpressure to give 1.12 g of a brown solid in 33% yield.
According to the analysis of related databases, 330786-24-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; HANGZHOU HERTZ PHARMACEUTICAL CO LTD; ZHOU, XINGLU; HAN, LING; GE, ZHEN; LIU, XINGGUO; LUO, WENHUA; LIU, WENHUA; (27 pag.)CN104844609; (2016); B;,
Pyrimidine | C4H4N2 – PubChem,
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