Electric Literature of 3286-55-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3286-55-3, name is 6-Chloro-2-methoxypyrimidin-4-amine, molecular formula is C5H6ClN3O, molecular weight is 159.57, as common compound, the synthetic route is as follows.
Step 1: 4-(6-amino-2-methoxypyrimidin-4-yl)benzonitrile To a mixture of 6-chloro-2-methoxypyrimidin-4-amine (Ark Pharm, catNo.AK-25131: 1.3 g, 8.0 mmol), (4-cyanophenyl)boronic acid (1.41 g, 9.60 mmol) and sodium carbonate (1.7 g, 16 mmol) in 1,4-dioxane (15 mL) and water (5 mL) was added dichloro(bis{di-tert-butyl[4-(dimethylamino)phenyl]phosphoranyl})palladium (170 mg, 0.24 mmol). The reaction mixture was purged with nitrogen then stirred at 95 C. overnight. The reaction mixture was cooled to room temperature then water (20 mL) was added. The resulting precipitate was collected via filtration then dried to give the desired product (1.7 g, 94%), which was used in the next step without further purification. LC-MS calculated for C12H11N4O (M+H)+: m/z=227.1. found 227.1.
Statistics shows that 3286-55-3 is playing an increasingly important role. we look forward to future research findings about 6-Chloro-2-methoxypyrimidin-4-amine.
Reference:
Patent; Incyte Corporation; He, Chunhong; Li, Zhenwu; Wu, Liangxing; Yao, Wenqing; Zhang, Fenglei; (84 pag.)US2016/289238; (2016); A1;,
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