Adding a certain compound to certain chemical reactions, such as: 34415-10-6, 2-Methyl-6-oxo-1,6-dihydropyrimidine-4-carboxylic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 2-Methyl-6-oxo-1,6-dihydropyrimidine-4-carboxylic acid, blongs to pyrimidines compound. Quality Control of 2-Methyl-6-oxo-1,6-dihydropyrimidine-4-carboxylic acid
Preparation of 6-chloro-2-methylpyrimidine-4-carbonyl chloride:To 920 mg (5.97 mmol) of 6-hydroxy-2-methylpyrimidine-4-carboxylic acid was added 13 mL of POCl3. The mixture was heated at reflux for 1 h, then concentrated in vacuo to a brown oil. This was suspended in 25 mL of pentane and extracted with water (2 x 10 mL). The combined water layers were back extracted with pentane (1 x 25 mL), then the combined pentane layers were washed again with water (2 x 10 mL), dried over MgSO4, filtered, and concentrated to 494 mg (43%) of a colorless oil.
The synthetic route of 34415-10-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SIRTRIS PHARMACEUTICALS, INC.; WO2009/61453; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia