Application of 355806-00-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 355806-00-7, name is (3R,5S,6E)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-[(methanesulfonyl) methylamino]pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid tert-butyl ester. A new synthetic method of this compound is introduced below.
In a three-necked flask with a condenser, rosuvastatin tert-butyl ester 50.0g, 12.0g (+/-) – phenethylamine and 130ml toluene, stirring for reaction at 100 ~ 110 degrees for about 12 hours, the reaction was complete after HPLC detection of raw materials, slightly cooled, was added 80ml of water, rhoEta = 5 with concentrated hydrochloric acid, points to the water layer, the oil layer was concentrated to dryness to give a reddish brown oil. In the above oil Added 250ml methyl tert-butyl ether, warmed to a clear, refluxed 10min, naturally cooled to 25-30 C, a large amount of white solid Precipitation, stirring crystallization 2h, filtered and dried, weighed 49.5g, a yield of 91.0% by liquid detection, the corresponding isomer is 0.18%
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,355806-00-7, its application will become more common.
Reference:
Patent; Zhejiang Jingxin Pharmaceutical Co., Ltd.; Shangyu Jing Xin Pharmaceutical Co., Ltd.; Zhu Jianrong; Zhong Hongban; Zhang Zhongliang; Wang Faping; Chen Jianyang; (8 pag.)CN104529908; (2017); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia