A new synthetic route of 35621-01-3

Here is just a brief introduction to this compound(35621-01-3)Product Details of 35621-01-3, more information about the compound(Piperidin-4-amine dihydrochloride) is in the article, you can click the link below.

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Synthesis of 4-aminopiperidine》. Authors are Yakhontov, L. N.; Yatsenko, S. V.; Rubtsov, M. V..The article about the compound:Piperidin-4-amine dihydrochloridecas:35621-01-3,SMILESS:NC1CCNCC1.[H]Cl.[H]Cl).Product Details of 35621-01-3. Through the article, more information about this compound (cas:35621-01-3) is conveyed.

Hydrogenation of 4-aminopyridine in alc. HCl over Pt at room temperature and 80 atm. H gave 16.5% 4-aminopiperidine-2HCl (I), m. 331-3° (picrate m. 245°). Hydrogenation of isonicotinic hydrazide in 4% HCl over Pt at room temperature gave 76% isonipecotinic hydrazide-2HCl, m. 240-2°. This treated with NaNO2 at -5°, then concentrated, and the resulting precipitate extracted with hot EtOH gave after refluxing 6 hrs. further with concentrated HCl 35% 4-aminopiperidine, isolated as HCl salt identical with the above. Hydrogenation of isonicotinic acid-HCl in 4% HCl over Pt gave isonipecotinic acid-HCl, decompose 299°, which treated with NaN3 in the presence of H2SO4 in C6H6 at 40° gave after aqueous treatment with NaOH 66% 4-aminopiperidine, isolated as HCl salt. Isonipecotinic acid HCl salt (II) and HN3 in H2SO4 and C6H6 gave at 80° 62% 4-aminopiperidine HCl salt. Refluxing II with NaO2CH and HCO2H 3 hrs. gave 44% 1-formylisonipecotinic acid, m. 136-38°. Heating I with HCO2Na in HCONH2 7 hrs. gave after aqueous treatment 62.5% 1-formyl-4-formamidopiperidine, m. 77-9°.

Here is just a brief introduction to this compound(35621-01-3)Product Details of 35621-01-3, more information about the compound(Piperidin-4-amine dihydrochloride) is in the article, you can click the link below.

Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia