Related Products of 3680-69-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3680-69-1, name is 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine, molecular formula is C6H4ClN3, molecular weight is 153.5691, as common compound, the synthetic route is as follows.
To a suspension of commercial 4-chloro-7H-pyrrolo[2,3-d]pyrimidine 10.75 g (70.00 mmol) in 150mL DCM, and added 1-bromopyrrolidine-2,5-dione (18.69 g, 105.00 mmol) at ambient temperature overnight. Upon the reaction completion, large amounts of precipitates formed. The precipitates were collected by filtration, and the filtrate was removed under reduced pressure to get the solid, washed with DCM, to yield of the title compound as yellow solid (15.00 g, 92% yield). 1H NMR (400 MHz, DMSO) delta 12.97(s, 1H), 8.63 (s, 1H), 7.95 (d, J 2.6 Hz, 1H).
Statistics shows that 3680-69-1 is playing an increasingly important role. we look forward to future research findings about 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine.
Reference:
Article; Zhang, Chufeng; Pei, Heying; He, Jun; Zhu, Jiali; Li, Weimin; Niu, Ting; Xiang, Mingli; Chen, Lijuan; European Journal of Medicinal Chemistry; vol. 169; (2019); p. 121 – 143;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia