In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 49844-90-8, name is 4-Chloro-2-(methylthio)pyrimidine, the common compound, a new synthetic route is introduced below. Computed Properties of C5H5ClN2S
Step 1: In a sealed vial under nitrogen, 4-chloro-2-methylthiopyrimidine 18 (0.24 mL, 2.0 mmol, 2.0 eq) is added to 4-chlorophenylboronic acid (156 mg, 1 mmol, 1 .0 eq), Na2C03 (530 mg, 5 mmol, 5.0 eq) and tetrakis(triphenylphosphine) palladium (0) (57.8 mg, 0.05 mmol, 0.05 eq) in a degassed mixture of toluene (4 mL), EtOH (0.8 mL) and H20 (0.2 mL). The reaction is heated at 90C for 18 h. After cooling, the reaction is diluted with water and EtOAc and the aqueous layer is acidified by HCI 1 N to pH 3-4 before being extracted with EtOAc. The combined organic layers are dried over anhydrous Na2S04 and evaporated under reduced pressure. The residue is purified by flash chromatography (Heptane/EtOAc 50:1 ) to afford intermediate 19. LC-MS conditions: LC-MS 5.
The synthetic route of 49844-90-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ACTELION PHARMACEUTICALS LTD; AISSAOUI, Hamed; BOSS, Christoph; CIANA, Claire-Lise; SIEGRIST, Romain; WO2014/72903; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia