Reference of 26452-81-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 26452-81-3, name is 4-Chloro-6-methoxypyrimidine, molecular formula is C5H5ClN2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A microwave vial containing 4-chloro-6-methoxypyrimidine (0.290 g, 2.007mmol), (5-chloro-2-fluorophenyl)boronic acid (0.35 g, 2.007 mmol) and Na2CO3 (0.2 13 g, 2.007 mmol) in DME (10 mL), EtOH (1.250 mL) and water (1.250 mL) was purged with N2 for several mm. Then PdC12(dppf)-CH2C12 adduct (0.082 g, 0.100 mmol) was added and the vial was capped. The reaction was heated in a microwave at 100 °C for 1h. The reaction mixture was then diluted with water and extracted with EtOAc. Theorganic layer was washed with brine and then concentrated to give an orange-brownresidue. Purification by normal phase chromatography gave 4-(5 -chloro-2-fluorophenyl)- 6-methoxypyrimidine (400 mg, 84percent yield) as white crystals.4-Chloro-2-(6-methoxypyrimidin-4-yl)aniline was synthesized according to theprocedure described in Intermediate 5, by replacing (5-chloro-2-fluorophenyl)boronic acid with 4-chloro-2-(4,4,5 ,5 -tetramethyl- 1,3 ,2-dioxaborolan-2-yl)aniline. MS(ESI) m/z:236.3 (M+H). ?H NMR (400MHz, CDC13) oe 8.78 (s, 1H), 7.49 (d, J=2.4 Hz, 1H), 7.15 (dd, J=8.6, 2.4 Hz, 1H), 6.99 (d, J0.9 Hz, 1H), 6.66 (d, J=8.6 Hz, 1H), 4.02 (s, 3H).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 26452-81-3, 4-Chloro-6-methoxypyrimidine.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; CORTE, James R.; DE LUCCA, Indawati; FANG, Tianan; YANG, Wu; WANG, Yufeng; DILGER, Andrew K.; PABBISETTY, Kumar Balashanmuga; EWING, William R.; ZHU, Yeheng; WEXLER, Ruth R.; PINTO, Donald J. P.; ORWAT, Michael J.; SMITH, Leon M. II; WO2015/116886; (2015); A1;,
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