A new synthetic route of 4316-98-7

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4316-98-7, its application will become more common.

Reference of 4316-98-7 ,Some common heterocyclic compound, 4316-98-7, molecular formula is C4H5ClN4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A mixture of 4-(1-(2,2-difluoroethyl)piperidin-4-yl)benzoic acid (837 mg), 6- chloro-4,5-diaminopyrimidine (494 mg) in POCI3 (10 ml.) was heated at 120 C for 16 hrs. After it was cooled to room temperature, the residue was washed several times with ether. Then the residue was dissolved in small amount of MeOH, purified by silica gel column using 5-25% of MeOH in CH2CI2 as eluent to give 6-chloro-8-(4-(1-(2,2- difluoroethyl)piperidin-4-yl)phenyl)-9H-purine. LCMS-ESI+ (m/z): [M+H]+ calcd for C 8H1 8 CIF2N5: 378.1 ; found: 378.2.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4316-98-7, its application will become more common.

Reference:
Patent; GILEAD SCIENCES, INC.; DU, Zhimin; GUERRERO, Juan, Arnaldo; KAPLAN, Joshua, Aaron; KNOX, JR., John Edward; NADUTHAMBI, Devan; PHILLIPS, Barton, W.; VENKATARAMANI, Chandrasekar; WANG, Peiyuan; WATKINS, William, J.; ZABLOCKI, Jeff; WO2015/187684; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia