Related Products of 4318-56-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4318-56-3, name is 6-Chloro-3-methylpyrimidine-2,4(1H,3H)-dione, molecular formula is C5H5ClN2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
3-Methyl-6-chloro uracil (12 g, 76 mmol),Compound 3 (17.2 g, 80 mmol) and K2CO3 (10 g,80 mmol) in DMSO (100 mL) was stirred for 2 h and the reaction was diluted with water and extracted with EtOAc. The organic phase was dried over MgSO4 and the solvent was removed. Purification by column chromatography gave 4,13.2 g (60% yield).
According to the analysis of related databases, 4318-56-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Shanghai Institute of Pharmaceutical Industry; China Pharmaceutical Industry Research Institute; Chen, Wu; Liu, Xiangkui; Ji, Zhongde; Zhu, Xueyan; Yuan, Zhedong; (10 pag.)CN105418580; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia