A new synthetic route of 4,6-Dichloro-2-(trifluoromethyl)pyrimidine

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,705-24-8, its application will become more common.

Adding a certain compound to certain chemical reactions, such as: 705-24-8, 4,6-Dichloro-2-(trifluoromethyl)pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 705-24-8, blongs to pyrimidines compound. Recommanded Product: 4,6-Dichloro-2-(trifluoromethyl)pyrimidine

To 4,6-dichloro-2-(trifluoromethyl)pyrimidine (300 mg 1.38 mmol) in Dioxane (3 ml) was added ammonia solution (1 ml). The reaction was heated under microwave activation, at 100C for 20 min. After cooling, excess solvent was evaporated under reduced pressure. The obtained residue was taken to the next step without further purification. LC/MS: m/z 198 (M+H)+

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,705-24-8, its application will become more common.

Reference:
Patent; HELMHOLTZ-ZENTRUM FUeR INFEKTIONSFORSCHUNG GMBH; AHMED, Ahmed S. A.; EMPTING, Martin; HAMED, Mostafa; HARTMANN, Rolf W.; HAUPENTHAL, Joerg; HASTERKAMP, Thomas; KAMAL, Ahmed A. M.; MAURER, Christine K.; ROeHRIG, Teresa; SCHUeTZ, Christian; YAHIAOUI, Samir; ZENDER, Michael; (128 pag.)WO2020/7938; (2020); A1;,
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