Reference of 1211522-68-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1211522-68-7, name is 4,6-Dichloro-3-methyl-1H-pyrazolo[3,4-d]pyrimidine. A new synthetic method of this compound is introduced below.
To a solution of ethanol (0.227 g, 4.93 mmol) in THF (60 mL) was added sodium hydride(0.591, 14.78 mmol) in ice bath. After 20 mi 4,6-dichloro-3-methyl-1H-pyrazolo-[3,4-d]-pyrimidine (Ig, 4.93 mmol) was added. The reaction mixture was gradually warmed to room temperature and then stirred overnight. Then, the mixture was diluted with water (20 mL), concentrated to remove solvent and diluted with ethyl acetate (220 mL). The organic layer was washed with water (60 mL x2), dried over Na2SO4, filtered and concentrated. The crudewas used in next step without further purification. Yield: 86%.LCMS: 213 [M+H]. tR 2.775 mins. (LCMS condition 1)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1211522-68-7, its application will become more common.
Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; GLAXOSMITHKLINE (CHINA) R&D COMPANY LIMITED; DING, Xiao; LIU, Qian; SANG, Yingxia; STASI, Luigi Piero; WAN, Zehong; ZHAO, Baowei; EDGE, Colin Michael; WO2015/113452; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia