Synthetic Route of 183438-24-6 , The common heterocyclic compound, 183438-24-6, name is 5-Bromo-2-iodopyrimidine, molecular formula is C4H2BrIN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
A mixture of potassium fluoride (1.77g) and cuprous iodide (5.79g) was stirred and heated together using a heat gun under vacuum (-1 mm) for 20min. After cooling, dimethyl formamide (20ML) and N-METHYL PYRROLIDINONE (20ML) were added followed by (trifluoromethyl) trimethylsilane (4. 1ML) and 5-BROMO-2-IODOPYRIMIDINE (6.5g). The mixture was stirred at rt for 5h and then the brown solution was poured into 6N ammonia solution. The product was extracted into ethyl acetate and the extracts were washed with sodium bicarbonate solution and brine and then dried (NA2SO4) and evaporated. Chromatography on silica gel (elution with 20-50% DICHLOROMETHANE in pentane) gave the title compound (D30) as a white solid (2. 4G). 1 H NMR (CDCI3) : 8.97 (2H, s).
The synthetic route of 183438-24-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GLAXO GROUP LIMITED; WO2004/101546; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia