Reference of 7752-78-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 7752-78-5, name is 5-Bromo-2-methylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows.
This compound was synthezised according to J. Am. Chem. Soc, 2011, 133, 6948-6951. To a solution of 5-bromo-2-methylpyrimidine (5.78 mmol) and 4-isoxazoleboronic acid pinacol ester (6.07 mmol) in DMSO (40 ml_) was added a solution of potassium fluoride (17.30 mmol) in water (17 ml_). The mixture was flushed with argon, Pd(dppf)CI2.DCM (0.58 mmol) was added and the mixture was heated for 48h at 130¡ãC. It was filtered over a pad of Celite and washed with EtOAc. The filtrate was partitioned between water and EtOAc and the aqueous phase was extracted twice with EtOAc. The combined organic phases were dried over MgS04 and concentrated in vacuo. The crude was purified by CC using DCM/MeOH from 1/0 to 95/5 to give the title compound as brown oil. LC-MS (A): tR = 0.43 min; [M+ H]+: 134.10
According to the analysis of related databases, 7752-78-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ACTELION PHARMACEUTICALS LTD; HILPERT, Kurt; HUBLER, Francis; RENNEBERG, Dorte; STAMM, Simon; WO2014/97140; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia