Synthetic Route of 54326-16-8 , The common heterocyclic compound, 54326-16-8, name is 5-Chloropyrimidin-2(1H)-one, molecular formula is C4H3ClN2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
EXAMPLE 21 5-Chloro-1-(2-methoxyphenacyl)pyrimidin-2-one A solution of 5-chloropyrimidin-2-one (541 mg) and 2-bromo-2′-methoxyacetophenone (954 mg) in triethylamine (1 ml) and ethanol (25 ml) was stirred at ambient temperature for 31/2 hours. After evaporation of solvents, the residue was dissolved in ethyl acetate (150 ml) and this solution was washed with water (50 ml) and brine (25 ml), dried (MgSO4) and evaporated to give a foam. This was purified by preparative thin-layer chromatography on silica, developed in chloroform, then chloroform-ethanol (25:1) before crystallisation from ethyl acetate to give the title pyrimidinone (347 mg,); m.p. 123-125; lambdamax 248.5 nm epsilon 12200), 317.5 nm (epsilon 6700), lambdainf 229.5 nm (epsilon 12440), 349 nm (epsilon 2640).
The synthetic route of 54326-16-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Glaxo Group Limited; US4636509; (1987); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia